Females Battle to Suppress Their Inner Male

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Females Battle to Suppress Their Inner Male

Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.

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ژورنال

عنوان ژورنال: Cell

سال: 2009

ISSN: 0092-8674

DOI: 10.1016/j.cell.2009.11.036